Across TCGA cell cohorts, ARSI mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARSI-associated genes across cancer lineages are AMELY, CASP8AP2, and CCL25. Each is linked with ARSI in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSI-to-partner and partner-to-ARSI results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSI→partner) and Y-score (partner→ARSI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AMELY →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	CASP8AP2 →	+0.615	+3.064	.005	.009	3	1
LARGE_INTESTINE	CCL25 →	+0.693	+3.302	<.001	.008	3	1
LARGE_INTESTINE	PLPPR1 →	+0.436	+3.285	<.001	.008	3	1
LARGE_INTESTINE	SCRG1 →	+0.017	+2.793	.004	.002	3	1
LARGE_INTESTINE	MTNR1A →	+0.519	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

ARSI survival (RNA) · tumor vs normal (RNA) · all ARSI data types