ARSG

Across TCGA cell cohorts, ARSG mutation is significantly associated with the RNA expression of many other genes, with 876 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARSG-associated genes across cancer lineages are GRK3, GGA1, and ANKRD54. Each is linked with ARSG in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSG-to-partner and partner-to-ARSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRK3 grouped by ARSG-low versus ARSG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSG→partner) and Y-score (partner→ARSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRK3 →	+0.907	+2.588	<.001	.004	3	1
LARGE_INTESTINE	GGA1 →	+0.598	+2.502	.003	.005	3	1
LARGE_INTESTINE	ANKRD54 →	+0.517	+2.588	.001	.004	3	1
LARGE_INTESTINE	CBY1 →	+0.681	+3.330	<.001	.002	3	1
LARGE_INTESTINE	POLDIP3 →	+0.546	+2.502	.003	.005	3	1
LARGE_INTESTINE	MIOX →	+0.237	+2.502	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 876 associations by consensus.

GRK3 by ARSG expression — LARGE_INTESTINE

Explore this box plot interactively →