ARSG

Across TCGA cell cohorts, ARSG mutation is significantly associated with the mutation status of many other genes, with 6,367 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARSG-associated genes across cancer lineages are MAK, GTF2IRD1, and CYFIP2. Each is linked with ARSG in more than 5 cancer types. Because this analysis shows association rather than direction, both ARSG-to-partner and partner-to-ARSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAK grouped by ARSG-low versus ARSG-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSG→partner) and Y-score (partner→ARSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAK →	+5.415	+5.415	.004	.004	1	6
OVARY	GTF2IRD1 →	+4.415	+4.977	.007	.007	1	4
SKIN	CYFIP2 →	+4.824	+5.392	.004	.004	1	4
SKIN	KDM2B →	+4.239	+5.053	.007	.007	1	4
SKIN	USF2 →	+4.824	+5.392	.004	.004	1	4
OVARY	NFATC2 →	+5.415	+5.415	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,367 associations by consensus.

MAK by ARSG expression — OVARY

Explore this box plot interactively →