ARSD

Across TCGA patient cohorts, ARSD protein abundance is significantly associated with the RNA expression of many other genes, with 7,115 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ARSD-associated genes across cancer lineages are PNPLA4, PDSS1, and SMIM14. Each is linked with ARSD in more than 3 cancer types. Because this analysis shows association rather than direction, both ARSD-to-partner and partner-to-ARSD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARSD versus PNPLA4 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSD→partner) and Y-score (partner→ARSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PNPLA4 →	+0.987	+0.419	<.001	<.001	3	4
UCEC	PDSS1 →	-0.634	-0.363	.001	.001	3	4
BRCA	SMIM14 →	+0.865	+0.407	.003	.001	3	4
LUAD	LINC02718 →	+0.599	+0.298	<.001	.004	3	4
LUAD	METTL8 →	-0.429	-0.602	.002	<.001	3	3
LUAD	KDM5D →	-2.039	-0.429	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,115 associations by consensus.

ARSD vs PNPLA4 — BRCA

Explore this scatter interactively →