ARSD

Across TCGA patient cohorts, ARSD mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARSD-associated genes across cancer lineages are Notch1, Shc_pY317, and STAT3_pY705. Each is linked with ARSD in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSD-to-partner and partner-to-ARSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ARSD-low versus ARSD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSD→partner) and Y-score (partner→ARSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.142	+2.472	.005	.010	3	2
UCEC	Shc_pY317 →	-0.160	-2.115	.003	.017	3	2
UCEC	STAT3_pY705 →	-0.418	-1.990	<.001	.009	3	2
UCEC	TFRC →	+0.454	+1.584	.017	.019	3	2
UCEC	ATM →	-0.584	-3.571	<.001	.002	3	2
UCEC	EGFR →	-0.185	-2.115	.001	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by ARSD expression — UCEC

Explore this box plot interactively →