ARSB

Across TCGA patient cohorts, ARSB mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARSB-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and INPP4B. Each is linked with ARSB in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSB-to-partner and partner-to-ARSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ARSB-low versus ARSB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSB→partner) and Y-score (partner→ARSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.559	+3.008	.006	.019	3	2
COAD	Caspase-7-cleavedD198 →	+1.749	+3.008	<.001	.019	3	2
UCEC	INPP4B →	-0.318	-2.700	.008	.005	3	2
UCEC	STAT3_pY705 →	-0.339	-2.169	<.001	.003	3	2
UCEC	TFRC →	+0.444	+1.415	.025	.046	3	2
UCEC	4E-BP1 →	+0.336	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by ARSB expression — COAD

Explore this box plot interactively →