ARSA

Across TCGA pan-cancer cohorts, ARSA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ARSA data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ARSA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ARSA expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where ARSA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.935	1.000	.004	45	view →
UCEC	DFS	Median	All	0.935	0.769	.010	14	view →
LSCC	OS	Median	II,III,IV	0.542	0.913	<.001	14	view →
PDAC	OS	Tertile	III,IV	0.291	0.903	.002	12	view →
CCRCC	OS	Median	III,IV	0.985	0.237	.017	11	view →
LUAD	OS	Median	All	1.000	0.648	.002	9	view →
GBM	DFS	Tertile	All	0.254	0.406	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ARSA–HNSC (OS)

Open the HNSC breakdown →