ARSA

Across TCGA patient cohorts, ARSA mutation is significantly associated with the RNA expression of many other genes, with 732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARSA-associated genes across cancer lineages are CDK12, OR10A4, and RIMKLA. Each is linked with ARSA in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSA-to-partner and partner-to-ARSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK12 grouped by ARSA-low versus ARSA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSA→partner) and Y-score (partner→ARSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDK12 →	+0.510	+2.591	.009	.006	3	2
SKCM	OR10A4 →	+0.031	+2.560	<.001	.004	3	2
SKCM	RIMKLA →	+0.606	+3.331	.004	.005	3	2
UCEC	HYKK →	+0.563	+3.818	<.001	<.001	3	2
SKCM	PTPN1 →	+0.493	+3.331	.008	.005	3	2
SKCM	RNA5SP192 →	+0.069	+3.900	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 732 associations by consensus.

CDK12 by ARSA expression — SKCM

Explore this box plot interactively →