ARSA

Across TCGA patient cohorts, ARSA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARSA-associated genes across cancer lineages are ATM, MEK1_p_S217_S221, and Src_pY527. Each is linked with ARSA in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSA-to-partner and partner-to-ARSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ARSA-low versus ARSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSA→partner) and Y-score (partner→ARSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.624	-3.000	.008	.036	3	2
SKCM	MEK1_p_S217_S221 →	-0.275	-2.987	.031	.035	3	1
SKCM	Src_pY527 →	-0.592	-3.000	.010	.035	3	1
SKCM	YB-1 →	+0.232	+3.169	.038	.019	3	1
SKCM	4E-BP1 →	+0.341	+3.169	.039	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.562	+3.009	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by ARSA expression — UCEC

Explore this box plot interactively →