ARSA

Across TCGA cell cohorts, ARSA mutation is significantly associated with the RNA expression of many other genes, with 387 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARSA-associated genes across cancer lineages are EIF3L, TNRC6B, and DESI1. Each is linked with ARSA in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSA-to-partner and partner-to-ARSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by ARSA-low versus ARSA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSA→partner) and Y-score (partner→ARSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.567	+3.067	.001	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.802	+3.364	<.001	.002	3	1
LARGE_INTESTINE	DESI1 →	+0.516	+3.451	.002	.002	3	1
LARGE_INTESTINE	SLC35A2 →	-0.677	-3.278	<.001	.006	3	1
LARGE_INTESTINE	MYEF2 →	-1.739	-3.278	.002	.006	3	1
LARGE_INTESTINE	CA2 →	+2.124	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 387 associations by consensus.

EIF3L by ARSA expression — LARGE_INTESTINE

Explore this box plot interactively →