Across TCGA cell cohorts, ARRDC5 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARRDC5-associated genes across cancer lineages are TNP1, DEFA3, and ODF1. Each is linked with ARRDC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARRDC5-to-partner and partner-to-ARRDC5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC5→partner) and Y-score (partner→ARRDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.160	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1
SKIN	ODF1 →	+0.026	+6.022	<.001	.001	3	1
SKIN	DCD →	+0.068	+4.977	.001	.007	3	1
STOMACH	KRTAP10-7 →	+0.020	+4.285	<.001	.007	3	1
BLOOD_Leukemia	LGI1 →	+0.122	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

ARRDC5 survival (RNA) · tumor vs normal (RNA) · all ARRDC5 data types