ARRDC4

Across TCGA cell cohorts, ARRDC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,053 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARRDC4-associated GO terms across cancer lineages are Meiotic chromosome segregation, Regulation of endoplasmic reticulum unfolded protein response, and Cellular response to tumor cell. Each is linked with ARRDC4 in more than 8 cancer types. Because this analysis shows association rather than direction, both ARRDC4-to-partner and partner-to-ARRDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic chromosome segregation grouped by ARRDC4-low versus ARRDC4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC4→partner) and Y-score (partner→ARRDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Meiotic chromosome segregation →	-0.134	-1.199	<.001	.001	3	9
PANCREAS	Regulation of endoplasmic reticulum unfolded protein response →	+0.101	+1.658	<.001	<.001	3	9
LIVER	Cellular response to tumor cell →	+0.164	+1.138	.006	.003	3	9
LUNG_NSCLC_LUSC	Homologous chromosome segregation →	-0.174	-1.935	<.001	.007	3	8
UPPER_AERODIGESTIVE_TRACT	Response to steroid hormone →	+0.091	+2.000	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Metaphase chromosome alignment →	-0.069	-1.049	.002	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,053 associations by consensus.

Meiotic chromosome segregation by ARRDC4 expression — SOFT_TISSUE

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