ARRDC3

Across TCGA patient cohorts, ARRDC3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARRDC3-associated genes across cancer lineages are ACC1, Rad50, and EGFR_pY1068. Each is linked with ARRDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARRDC3-to-partner and partner-to-ARRDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ARRDC3-low versus ARRDC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC3→partner) and Y-score (partner→ARRDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.296	+2.820	.024	.035	3	2
UCEC	Rad50 →	-0.217	-1.584	.013	.019	3	2
UCEC	EGFR_pY1068 →	-0.216	-1.807	.016	.025	3	1
UCEC	A-Raf_pS299 →	-0.108	-1.700	.011	.042	3	1
UCEC	ERK2 →	+0.180	+2.115	.009	.016	3	1
UCEC	FASN →	+0.388	+2.115	.006	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ACC1 by ARRDC3 expression — UCEC

Explore this box plot interactively →