ARRDC3

Across TCGA cell cohorts, ARRDC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,208 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ARRDC3-associated GO terms across cancer lineages are Regulation of ubiquitin-protein transferase activity, Macroautophagy, and T-helper 17 cell differentiation. Each is linked with ARRDC3 in more than 12 cancer types. Because this analysis shows association rather than direction, both ARRDC3-to-partner and partner-to-ARRDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of ubiquitin-protein transferase activity grouped by ARRDC3-low versus ARRDC3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC3→partner) and Y-score (partner→ARRDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of ubiquitin-protein transferase activity →	+0.124	+1.248	<.001	<.001	3	13
STOMACH	Macroautophagy →	+0.071	+1.062	.001	.005	3	12
URINARY_TRACT	T-helper 17 cell differentiation →	+0.130	+1.039	<.001	<.001	3	12
BREAST	Positive regulation of cell-substrate junction organization →	+0.118	+1.344	<.001	<.001	3	11
OVARY	Positive regulation of post-translational protein modification →	+0.065	+1.376	.002	<.001	3	11
SKIN	Positive regulation of protein K48-linked ubiquitination →	+0.107	+0.928	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

Regulation of ubiquitin-protein transferase activity by ARRDC3 expression — BREAST

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