ARRDC2

Across TCGA patient cohorts, ARRDC2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARRDC2-associated genes across cancer lineages are Lck, Caspase-7-cleavedD198, and Chk2. Each is linked with ARRDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARRDC2-to-partner and partner-to-ARRDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ARRDC2-low versus ARRDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC2→partner) and Y-score (partner→ARRDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.240	+2.459	.013	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.874	+3.169	.002	.018	3	1
UCEC	Chk2 →	-0.230	-2.459	.042	.020	3	1
UCEC	IGFBP2 →	-1.009	-2.459	.001	.020	1	1
UCEC	Notch1 →	+0.177	+2.459	.009	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Lck by ARRDC2 expression — UCEC

Explore this box plot interactively →