ARRDC2

Across TCGA cell cohorts, ARRDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,336 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARRDC2-associated GO terms across cancer lineages are Negative regulation of inflammasome-mediated signaling pathway, Cellular response to chemical stress, and Negative regulation of hyaluronan biosynthetic process. Each is linked with ARRDC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ARRDC2-to-partner and partner-to-ARRDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of inflammasome-mediated signaling pathway grouped by ARRDC2-low versus ARRDC2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC2→partner) and Y-score (partner→ARRDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of inflammasome-mediated signaling pathway →	+0.084	+0.935	.002	.005	3	8
SOFT_TISSUE	Cellular response to chemical stress →	+0.046	+1.224	.001	.003	3	7
KIDNEY	Negative regulation of hyaluronan biosynthetic process →	+0.176	+0.845	<.001	.004	2	8
LUNG_SCLC	Regulation of blood vessel branching →	+0.157	+1.468	.004	.009	3	7
LUNG_NSCLC_LUSC	Negative regulation of lymphocyte mediated immunity →	+0.140	+0.632	<.001	.009	3	7
CNS	Interferon-mediated signaling pathway →	+0.101	+0.476	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,336 associations by consensus.

Negative regulation of inflammasome-mediated signaling pathway by ARRDC2 expression — PANCREAS

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