ARRDC2

Across TCGA cell cohorts, ARRDC2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARRDC2-associated genes across cancer lineages are ELOA3DP, SLC32A1, and PAX1. Each is linked with ARRDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARRDC2-to-partner and partner-to-ARRDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by ARRDC2-low versus ARRDC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC2→partner) and Y-score (partner→ARRDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.026	+2.688	<.001	.008	3	2
BLOOD_Leukemia	SLC32A1 →	+0.777	+3.901	<.001	.006	3	1
BLOOD_Leukemia	PAX1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	1
BLOOD_Leukemia	CYP39A1 →	+0.247	+3.769	<.001	.008	3	1
BLOOD_Leukemia	ANKRD30BL →	+1.083	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ELOA3DP by ARRDC2 expression — LARGE_INTESTINE

Explore this box plot interactively →