Across TCGA patient cohorts, ARRDC1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARRDC1-associated genes across cancer lineages are ER-alpha_pS118, ER-alpha, and S6. Each is linked with ARRDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARRDC1-to-partner and partner-to-ARRDC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC1→partner) and Y-score (partner→ARRDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	+0.414	+2.335	.006	.018	3	1
UCEC	ER-alpha →	+0.723	+3.013	.038	.018	3	1
UCEC	S6 →	-0.223	-1.700	.049	.044	3	1
UCEC	p62 Lck ligand →	+0.325	+1.700	.018	.044	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

ARRDC1 survival (RNA) · tumor vs normal (RNA) · all ARRDC1 data types