Across TCGA cell cohorts, ARRDC1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARRDC1-associated genes across cancer lineages are BTN1A1, C4orf50, and GUCA2A. Each is linked with ARRDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARRDC1-to-partner and partner-to-ARRDC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRDC1→partner) and Y-score (partner→ARRDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BTN1A1 →	+0.208	+4.095	<.001	.009	3	1
SKIN	C4orf50 →	+0.020	+4.684	<.001	.002	3	1
SKIN	GUCA2A →	+0.078	+4.273	<.001	.006	3	1
LARGE_INTESTINE	SLC5A5 →	+0.421	+3.716	<.001	.003	3	1
LARGE_INTESTINE	BVES →	+0.472	+3.355	.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

ARRDC1 survival (RNA) · tumor vs normal (RNA) · all ARRDC1 data types