ARRB2

Across TCGA pan-cancer cohorts, ARRB2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ARRB2 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ARRB2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARRB2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where ARRB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.913	1.000	.008	78	view →
PDAC	DFS	Tertile	III,IV	0.273	0.785	.014	15	view →
CCRCC	DFS	Quartile	All	0.474	1.000	.014	7	view →
GBM	OS	Quartile	All	0.703	0.941	.015	2	view →
HNSC	DFS	Tertile	III,IV	1.000	0.623	.040	2	view →
LSCC	OS	Tertile	III,IV	1.000	0.569	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ARRB2–COAD (DFS)

Open the COAD breakdown →