ARRB2

Across TCGA cell cohorts, ARRB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,832 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ARRB2-associated GO terms across cancer lineages are Regulation of synaptic transmission, dopaminergic, Adult walking behavior, and Beta-arrestin-dependent dopamine receptor signaling pathway. Each is linked with ARRB2 in more than 17 cancer types. Because this analysis shows association rather than direction, both ARRB2-to-partner and partner-to-ARRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of synaptic transmission, dopaminergic grouped by ARRB2-low versus ARRB2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRB2→partner) and Y-score (partner→ARRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of synaptic transmission, dopaminergic →	+0.388	+1.581	<.001	<.001	3	18
URINARY_TRACT	Adult walking behavior →	+1.000	+1.539	<.001	<.001	3	18
BLOOD_Myeloma	Beta-arrestin-dependent dopamine receptor signaling pathway →	+0.193	+1.108	<.001	.004	3	16
URINARY_TRACT	Desensitization of G protein-coupled receptor signaling pathway →	+0.209	+1.697	.008	.002	2	15
URINARY_TRACT	Negative adaptation of signaling pathway →	+0.209	+1.697	.008	.002	2	15
URINARY_TRACT	Adaptation of signaling pathway →	+0.209	+1.697	.008	.002	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,832 associations by consensus.

Regulation of synaptic transmission, dopaminergic by ARRB2 expression — STOMACH

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