ARRB1

Across TCGA cell cohorts, ARRB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,956 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARRB1-associated GO terms across cancer lineages are Regulation of protein localization to ciliary membrane, Negative regulation of protein localization to ciliary membrane, and Negative regulation of protein localization to cilium. Each is linked with ARRB1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ARRB1-to-partner and partner-to-ARRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to ciliary membrane grouped by ARRB1-low versus ARRB1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARRB1→partner) and Y-score (partner→ARRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of protein localization to ciliary membrane →	+0.150	+1.954	<.001	<.001	3	12
PANCREAS	Negative regulation of protein localization to ciliary membrane →	+0.139	+2.070	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Negative regulation of protein localization to cilium →	+0.145	+1.578	<.001	<.001	3	8
SOFT_TISSUE	Transdifferentiation →	-0.241	-1.779	.002	<.001	3	8
BLOOD_Leukemia	Negative regulation of interleukin-8 production →	+0.113	+1.999	<.001	<.001	3	8
SKIN	Regulation of low-density lipoprotein particle receptor catabolic process →	+0.165	+1.552	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,956 associations by consensus.

Regulation of protein localization to ciliary membrane by ARRB1 expression — BREAST

Explore this box plot interactively →