ARR3

Across TCGA patient cohorts, ARR3 mutation is significantly associated with the RNA expression of many other genes, with 1,736 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARR3-associated genes across cancer lineages are RNA5SP509, RPS27AP15, and TRAJ47. Each is linked with ARR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARR3-to-partner and partner-to-ARR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP509 grouped by ARR3-low versus ARR3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARR3→partner) and Y-score (partner→ARR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNA5SP509 →	+0.248	+7.977	<.001	.007	3	2
SKCM	RPS27AP15 →	+0.137	+4.628	<.001	.004	3	2
COAD	TRAJ47 →	+0.535	+3.636	.005	.006	3	2
LUSC	RNA5SP72 →	+0.556	+5.038	<.001	.009	3	2
LUSC	C1QBPP1 →	+0.114	+5.978	.001	.002	3	2
SKCM	SMR3A →	+0.909	+5.199	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,736 associations by consensus.

RNA5SP509 by ARR3 expression — LGG

Explore this box plot interactively →