ARPP21

Across TCGA patient cohorts, ARPP21 mutation is significantly associated with the RNA expression of many other genes, with 6,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPP21-associated genes across cancer lineages are WDHD1, DFFA, and UTP11. Each is linked with ARPP21 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARPP21-to-partner and partner-to-ARPP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDHD1 grouped by ARPP21-low versus ARPP21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPP21→partner) and Y-score (partner→ARPP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDHD1 →	+0.618	+1.423	<.001	<.001	3	4
UCEC	DFFA →	+0.431	+2.233	<.001	<.001	3	4
UCEC	UTP11 →	+0.282	+1.455	.007	<.001	3	4
UCEC	NRAS →	+0.419	+1.362	.003	.007	3	4
LUSC	NDC1 →	+0.425	+2.807	.002	.003	3	4
STAD	ITIH5 →	-1.191	-3.426	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,060 associations by consensus.

WDHD1 by ARPP21 expression — UCEC

Explore this box plot interactively →