ARPP21

Across TCGA cell cohorts, ARPP21 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,828 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARPP21-associated GO terms across cancer lineages are Negative regulation of adaptive immune response, Regulation of ATPase-coupled calcium transmembrane transporter activity, and Regulation of double-strand break repair. Each is linked with ARPP21 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARPP21-to-partner and partner-to-ARPP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of adaptive immune response grouped by ARPP21-low versus ARPP21-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPP21→partner) and Y-score (partner→ARPP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of adaptive immune response →	-0.108	-1.850	.001	.002	3	6
BLOOD_Lymphoma	Regulation of ATPase-coupled calcium transmembrane transporter activity →	-0.192	-1.244	<.001	<.001	3	6
BLOOD_Lymphoma	Regulation of double-strand break repair →	+0.073	+1.441	<.001	<.001	3	6
SOFT_TISSUE	DNA damage checkpoint signaling →	+0.063	+1.856	.003	.004	3	6
BLOOD_Leukemia	Regulation of termination of RNA polymerase II transcription →	+0.061	+2.077	<.001	<.001	3	6
BLOOD_Leukemia	Regulation of termination of DNA-templated transcription →	+0.061	+2.077	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,828 associations by consensus.

Negative regulation of adaptive immune response by ARPP21 expression — SOFT_TISSUE

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