ARPP21

Across TCGA cell cohorts, ARPP21 mutation is significantly associated with the RNA expression of many other genes, with 313 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARPP21-associated genes across cancer lineages are OR4N2, PRAMEF11, and FAM25A. Each is linked with ARPP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPP21-to-partner and partner-to-ARPP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N2 grouped by ARPP21-low versus ARPP21-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPP21→partner) and Y-score (partner→ARPP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4N2 →	+0.256	+4.000	<.001	.002	3	2
CNS	PRAMEF11 →	+0.095	+3.459	.009	.006	3	2
LUNG_SCLC	FAM25A →	+0.112	+4.058	<.001	.007	3	2
SKIN	ZNF705G →	+0.019	+3.297	.001	.002	3	2
LARGE_INTESTINE	CD300H →	+0.016	+2.678	<.001	.005	3	2
BLOOD_Myeloma	LRRC74A →	+0.013	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 313 associations by consensus.

OR4N2 by ARPP21 expression — CNS

Explore this box plot interactively →