ARPP21-AS1

Across TCGA pan-cancer cohorts, ARPP21-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ARPP21-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ARPP21-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ARPP21-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and UCS show a favorable association.

UCEC, UVM, and LUAD are the cancer types where ARPP21-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.109	0.679	<.001	108	view →
UVM	DFS	Tertile	All	0.104	0.769	<.001	99	view →
LUAD	OS	Tertile	All	0.526	0.835	<.001	96	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	81	view →
STAD	DFS	Tertile	All	0.399	0.665	.002	54	view →
LAML	DFS	Median	All	0.701	0.439	<.001	54	view →
UCS	DFS	Quartile	II,III,IV	0.804	0.204	<.001	50	view →
KIRC	DFS	Tertile	All	0.841	0.606	.001	48	view →
KICH	DFS	Tertile	All	0.102	0.848	.004	39	view →
LGG	OS	Median	All	0.950	0.839	<.001	39	view →
BLCA	OS	Tertile	All	0.188	0.687	.020	36	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ARPP21-AS1–UCEC (OS)

Open the UCEC breakdown →