ARPP19

Across TCGA patient cohorts, ARPP19 mutation is significantly associated with the RNA expression of many other genes, with 1,477 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPP19-associated genes across cancer lineages are RNA5SP419, RNA5SP421, and RNA5SP423. Each is linked with ARPP19 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPP19-to-partner and partner-to-ARPP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by ARPP19-low versus ARPP19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPP19→partner) and Y-score (partner→ARPP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP419 →	+0.665	+2.617	<.001	<.001	3	2
UCEC	RNA5SP421 →	+0.939	+2.755	<.001	<.001	3	2
UCEC	RNA5SP423 →	+0.664	+2.258	<.001	.001	3	2
UCEC	GCATP1 →	+0.296	+1.949	.005	.009	3	1
UCEC	DCP1A →	+0.546	+2.415	.002	.003	3	1
UCEC	ZNHIT3 →	+0.397	+2.831	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,477 associations by consensus.

RNA5SP419 by ARPP19 expression — UCEC

Explore this box plot interactively →