ARPP19

Across TCGA cell cohorts, ARPP19 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,880 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARPP19-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Regulation of heterochromatin organization, and Regulation of cell cycle checkpoint. Each is linked with ARPP19 in more than 13 cancer types. Because this analysis shows association rather than direction, both ARPP19-to-partner and partner-to-ARPP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by ARPP19-low versus ARPP19-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPP19→partner) and Y-score (partner→ARPP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of DNA damage checkpoint →	+0.084	+0.663	.001	.002	3	14
OVARY	Regulation of heterochromatin organization →	+0.096	+0.937	<.001	<.001	3	13
PANCREAS	Regulation of cell cycle checkpoint →	+0.104	+0.755	<.001	<.001	3	13
URINARY_TRACT	Circadian sleep/wake cycle →	+0.137	+0.649	.001	<.001	2	14
PANCREAS	Negative regulation of cell cycle process →	+0.065	+0.716	<.001	<.001	3	12
LARGE_INTESTINE	Protein deubiquitination →	+0.041	+0.624	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,880 associations by consensus.

Regulation of DNA damage checkpoint by ARPP19 expression — OVARY

Explore this box plot interactively →