ARPC5

Across TCGA patient cohorts, ARPC5 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPC5-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and P-Cadherin. Each is linked with ARPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPC5-to-partner and partner-to-ARPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ARPC5-low versus ARPC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPC5→partner) and Y-score (partner→ARPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.130	-2.571	.005	.011	3	2
UCEC	A-Raf_pS299 →	-0.153	-3.169	.005	.019	3	1
UCEC	P-Cadherin →	-0.175	-2.311	.009	.034	3	1
UCEC	Annexin-1 →	+0.670	+3.019	.006	.019	3	1
UCEC	Shc_pY317 →	-0.151	-3.000	.033	.036	3	1
UCEC	Smad4 →	-0.158	-2.302	.005	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by ARPC5 expression — UCEC

Explore this box plot interactively →