ARPC4-TTLL3

Across TCGA pan-cancer cohorts, ARPC4-TTLL3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ARPC4-TTLL3 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher ARPC4-TTLL3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARPC4-TTLL3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

KICH, SKCM, and BLCA are the cancer types where ARPC4-TTLL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.649	1.000	<.001	95	view →
SKCM	OS	Median	IV	1.000	0.257	.001	87	view →
BLCA	OS	Tertile	All	0.633	0.381	.001	54	view →
ACC	DFS	Quartile	All	0.272	0.704	<.001	45	view →
READ	OS	Tertile	All	1.000	0.801	.007	34	view →
LUSC	DFS	Tertile	III,IV	0.232	0.897	.005	32	view →
PAAD	DFS	Quartile	All	0.529	0.298	.017	24	view →
THYM	DFS	Tertile	All	1.000	0.651	.007	23	view →
HNSC	DFS	Median	III,IV	0.418	0.254	.004	22	view →
COAD	DFS	Quartile	All	0.817	0.553	.003	19	view →
KIRC	DFS	Median	All	0.554	0.706	.011	18	view →
MESO	DFS	Median	All	0.283	0.438	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ARPC4-TTLL3–KICH (DFS)

Open the KICH breakdown →