ARNTL2

Across TCGA patient cohorts, ARNTL2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARNTL2-associated genes across cancer lineages are ERCC1, EGFR_pY1068, and A-Raf_pS299. Each is linked with ARNTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARNTL2-to-partner and partner-to-ARNTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERCC1 grouped by ARNTL2-low versus ARNTL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNTL2→partner) and Y-score (partner→ARNTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERCC1 →	+0.201	+3.000	.023	.035	3	2
UCEC	EGFR_pY1068 →	-0.221	-1.807	.033	.027	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.459	.011	.019	3	1
UCEC	ERK2 →	+0.199	+2.321	.012	.006	3	1
UCEC	Heregulin →	-0.131	-1.807	.010	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.181	-2.308	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ERCC1 by ARNTL2 expression — SKCM

Explore this box plot interactively →