ARNTL

Across TCGA patient cohorts, ARNTL mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARNTL-associated genes across cancer lineages are eIF4E, INPP4B, and PCNA. Each is linked with ARNTL in more than 1 cancer types. Because this analysis shows association rather than direction, both ARNTL-to-partner and partner-to-ARNTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARNTL-low versus ARNTL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNTL→partner) and Y-score (partner→ARNTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.151	+1.378	.016	.008	3	2
UCEC	INPP4B →	-0.207	-2.115	.031	.016	3	2
UCEC	PCNA →	+0.183	+1.584	.004	.002	3	2
UCEC	ATM →	-0.310	-2.308	.022	.005	3	2
UCEC	C-Raf →	+0.164	+1.925	<.001	.004	3	2
UCEC	Cyclin-B1 →	+0.633	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

eIF4E by ARNTL expression — UCEC

Explore this box plot interactively →