ARNTL

Across TCGA cell cohorts, ARNTL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,957 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ARNTL-associated GO terms across cancer lineages are Protein K63-linked ubiquitination, Regulation of post-translational protein modification, and Endosomal transport. Each is linked with ARNTL in more than 11 cancer types. Because this analysis shows association rather than direction, both ARNTL-to-partner and partner-to-ARNTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K63-linked ubiquitination grouped by ARNTL-low versus ARNTL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNTL→partner) and Y-score (partner→ARNTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein K63-linked ubiquitination →	+0.065	+1.423	<.001	<.001	3	12
SOFT_TISSUE	Regulation of post-translational protein modification →	+0.054	+1.121	<.001	.004	3	11
BONE	Endosomal transport →	+0.049	+1.479	<.001	<.001	3	11
OVARY	Protein polyubiquitination →	+0.029	+0.723	<.001	<.001	3	11
SOFT_TISSUE	Regulation of protein modification by small protein conjugation or removal →	+0.056	+0.939	<.001	.009	3	11
OVARY	Negative regulation of protein catabolic process →	+0.060	+0.945	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,957 associations by consensus.

Protein K63-linked ubiquitination by ARNTL expression — BONE

Explore this box plot interactively →