ARNTL

Across TCGA cell cohorts, ARNTL mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARNTL-associated genes across cancer lineages are TFDP3, MSGN1, and SNTG2. Each is linked with ARNTL in more than 1 cancer types. Because this analysis shows association rather than direction, both ARNTL-to-partner and partner-to-ARNTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by ARNTL-low versus ARNTL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNTL→partner) and Y-score (partner→ARNTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	2
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	SNTG2 →	+0.156	+3.789	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.280	+3.688	<.001	.002	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

TFDP3 by ARNTL expression — LARGE_INTESTINE

Explore this box plot interactively →