ARNT2

Across TCGA patient cohorts, ARNT2 mutation is significantly associated with the RNA expression of many other genes, with 3,012 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARNT2-associated genes across cancer lineages are SNRNP40, YARS1, and RPS6KA1. Each is linked with ARNT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARNT2-to-partner and partner-to-ARNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRNP40 grouped by ARNT2-low versus ARNT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNT2→partner) and Y-score (partner→ARNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNRNP40 →	+0.618	+3.353	.003	.005	3	4
UCEC	YARS1 →	+0.407	+2.094	<.001	<.001	3	4
STAD	RPS6KA1 →	+0.732	+3.338	.002	.005	3	3
UCEC	MED18 →	+0.491	+2.072	<.001	<.001	3	3
STAD	SRRM1 →	+0.506	+3.194	.006	.009	2	4
STAD	RNU6-365P →	+0.244	+2.643	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,012 associations by consensus.

SNRNP40 by ARNT2 expression — SKCM

Explore this box plot interactively →