ARNT2

Across TCGA patient cohorts, ARNT2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARNT2-associated genes across cancer lineages are eIF4E, MEK1, and Rad50. Each is linked with ARNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARNT2-to-partner and partner-to-ARNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARNT2-low versus ARNT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARNT2→partner) and Y-score (partner→ARNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.191	+3.820	.004	<.001	3	2
UCEC	MEK1 →	+0.367	+2.070	.001	.001	3	2
UCEC	Rad50 →	-0.217	-1.523	.005	.008	3	2
UCEC	Cyclin-B1 →	+0.554	+1.777	.001	.002	3	2
UCEC	14-3-3_beta →	-0.079	-2.780	.013	.003	3	1
UCEC	ERCC1 →	-0.111	-1.415	.043	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by ARNT2 expression — UCEC

Explore this box plot interactively →