ARMS2

Across TCGA pan-cancer cohorts, ARMS2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ARMS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARMS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARMS2 is over-expressed in tumor, although a few such as BRCA and READ show the opposite, repressed pattern.

KIRC, BRCA, and LIHC are the cancer types where ARMS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARMS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.113	<.001	8	view →
BRCA	Female	All	−0.221	<.001	6	view →
LIHC	Male	All	+0.108	<.001	5	view →
CHOL	All	All	+0.172	.003	2	view →
READ	All	All	−0.107	.022	2	view →
KICH	All	All	−0.078	.015	2	view →
PRAD	All	All	−0.068	.025	2	view →
THCA	All	All	−0.059	.020	2	view →
LUAD	All	III,IV	−0.086	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ARMS2–KIRC

Open the KIRC breakdown →