ARMCX5

Across TCGA patient cohorts, ARMCX5 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARMCX5-associated genes across cancer lineages are A-Raf_pS299, Tuberin_pT1462, and ASNS. Each is linked with ARMCX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARMCX5-to-partner and partner-to-ARMCX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ARMCX5-low versus ARMCX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMCX5→partner) and Y-score (partner→ARMCX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.130	-2.000	.003	.030	3	2
UCEC	Tuberin_pT1462 →	+0.214	+1.495	.013	.034	3	2
UCEC	ASNS →	+0.387	+1.765	.004	.014	3	2
UCEC	Di-Ras3 →	-0.207	-3.906	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.126	-2.649	<.001	<.001	3	1
UCEC	eIF4G →	+0.234	+1.415	.045	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

A-Raf_pS299 by ARMCX5 expression — UCEC

Explore this box plot interactively →