ARMCX3

Across TCGA patient cohorts, ARMCX3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARMCX3-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and PDCD4. Each is linked with ARMCX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARMCX3-to-partner and partner-to-ARMCX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARMCX3-low versus ARMCX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMCX3→partner) and Y-score (partner→ARMCX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.485	+1.460	.004	.013	3	3
UCEC	MEK1 →	+0.388	+1.906	<.001	<.001	3	2
UCEC	PDCD4 →	-0.484	-2.415	<.001	.002	3	2
UCEC	ASNS →	+0.446	+1.485	<.001	.003	3	2
UCEC	ATM →	-0.292	-1.247	.027	.041	3	2
UCEC	Caspase-8 →	-0.225	-2.221	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by ARMCX3 expression — UCEC

Explore this box plot interactively →