ARMC6

Across TCGA pan-cancer cohorts, ARMC6 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ARMC6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARMC6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ARMC6 is over-expressed in tumor.

HNSC, COAD, and PDAC are the cancer types where ARMC6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARMC6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.109	<.001	10	view →
COAD	Male	All	+0.247	<.001	9	view →
PDAC	Male	All	+0.331	<.001	6	view →
LSCC	Male	II,III,IV	+0.326	<.001	6	view →
CCRCC	All	II,III,IV	+0.101	.002	6	view →
LUAD	All	All	+0.081	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ARMC6–HNSC

Open the HNSC breakdown →