ARMC6

Across TCGA patient cohorts, ARMC6 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARMC6-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and p38-MAPK_pT180_Y182. Each is linked with ARMC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARMC6-to-partner and partner-to-ARMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ARMC6-low versus ARMC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARMC6→partner) and Y-score (partner→ARMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.209	+3.169	.024	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.232	-3.321	.004	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.458	-2.321	.035	.034	3	1
UCEC	p62 Lck ligand →	+0.329	+3.331	.036	.005	3	1
UCEC	AMPK_pT172 →	+0.443	+3.169	.025	.019	3	1
UCEC	Lck →	+0.261	+3.584	.007	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by ARMC6 expression — UCEC

Explore this box plot interactively →