ARMC5

Across TCGA pan-cancer cohorts, ARMC5 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ARMC5 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher ARMC5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ARMC5 expression acts as an unfavorable survival marker, although some lineages such as PAAD and HNSC show a favorable association.

PAAD, HNSC, and LUAD are the cancer types where ARMC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.503	0.260	<.001	66	view →
HNSC	OS	Median	All	0.819	0.714	.009	26	view →
LUAD	DFS	Quartile	IV	0.449	0.891	.022	22	view →
SKCM	OS	Quartile	IV	0.833	0.326	.002	18	view →
UVM	DFS	Median	III,IV	0.885	0.462	.001	17	view →
COAD	OS	Median	All	0.724	0.867	.004	16	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	14	view →
CESC	OS	Median	All	0.904	0.841	.020	8	view →
BRCA	OS	Median	IV	0.937	0.609	.019	7	view →
SARC	DFS	Quartile	All	0.718	0.538	.007	7	view →
GBM	DFS	Median	All	0.351	0.218	.030	6	view →
ESCA	OS	Tertile	III,IV	0.435	0.689	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ARMC5–PAAD (OS)

Open the PAAD breakdown →