ARL8A

Across TCGA pan-cancer cohorts, ARL8A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARL8A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ARL8A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARL8A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where ARL8A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL8A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.088	<.001	11	view →
HNSC	Male	IV	+0.984	<.001	10	view →
LIHC	Male	II,III,IV	+0.935	<.001	9	view →
KICH	Female	All	−0.794	<.001	8	view →
KIRP	All	III,IV	+0.480	<.001	8	view →
KIRC	Female	All	+0.448	<.001	8	view →
BLCA	Female	All	+0.646	.002	6	view →
BRCA	All	III,IV	+0.610	<.001	6	view →
STAD	All	II,III,IV	+0.562	<.001	5	view →
ESCA	All	II,III,IV	+0.890	.004	4	view →
CHOL	Male	All	+1.771	<.001	3	view →
READ	All	All	+0.563	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARL8A–COAD

Open the COAD breakdown →