ARL8A

Across TCGA pan-cancer cohorts, ARL8A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ARL8A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ARL8A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ARL8A is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where ARL8A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL8A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.373	<.001	10	view →
LSCC	Female	II,III,IV	−0.563	<.001	9	view →
LUAD	Male	III,IV	−0.397	<.001	8	view →
CCRCC	Male	All	+0.165	<.001	5	view →
HNSC	Male	All	−0.178	.009	4	view →
PDAC	All	All	−0.187	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ARL8A–COAD

Open the COAD breakdown →