ARL6IP6

Across TCGA patient cohorts, ARL6IP6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL6IP6-associated genes across cancer lineages are Ku80, PKC-b-II_pS660, and Rictor_pT1135. Each is linked with ARL6IP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL6IP6-to-partner and partner-to-ARL6IP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ARL6IP6-low versus ARL6IP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL6IP6→partner) and Y-score (partner→ARL6IP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.416	+3.013	.002	.019	3	1
UCEC	PKC-b-II_pS660 →	-0.473	-3.000	.003	.037	3	1
UCEC	Rictor_pT1135 →	-0.129	-3.000	.029	.037	3	1
UCEC	INPP4B →	-0.427	-2.986	.022	.037	2	1
UCEC	p62 Lck ligand →	+0.665	+2.817	<.001	.036	2	1
UCEC	MEK1 →	+0.540	+3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ku80 by ARL6IP6 expression — UCEC

Explore this box plot interactively →