ARL6IP5

Across TCGA patient cohorts, ARL6IP5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL6IP5-associated genes across cancer lineages are A-Raf_pS299, MEK1, and Notch1. Each is linked with ARL6IP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL6IP5-to-partner and partner-to-ARL6IP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ARL6IP5-low versus ARL6IP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL6IP5→partner) and Y-score (partner→ARL6IP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.190	-3.169	.001	.019	3	2
UCEC	MEK1 →	+0.501	+3.169	.006	.019	3	1
UCEC	Notch1 →	+0.231	+2.321	.001	.035	3	1
UCEC	Annexin-1 →	+0.712	+2.827	.007	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.927	+3.019	.001	.019	3	1
UCEC	eIF4E →	+0.267	+2.321	.011	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by ARL6IP5 expression — UCEC

Explore this box plot interactively →