ARL6IP4

Across TCGA patient cohorts, ARL6IP4 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL6IP4-associated genes across cancer lineages are 14-3-3_beta, JNK2, and Smad4. Each is linked with ARL6IP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL6IP4-to-partner and partner-to-ARL6IP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ARL6IP4-low versus ARL6IP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL6IP4→partner) and Y-score (partner→ARL6IP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.136	-2.986	.019	.037	2	1
UCEC	JNK2 →	+0.322	+3.000	.005	.037	2	1
UCEC	Smad4 →	+0.160	+3.000	.022	.037	2	1
UCEC	C-Raf_pS338 →	-0.150	-3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

14-3-3_beta by ARL6IP4 expression — UCEC

Explore this box plot interactively →