ARL6IP1

Across TCGA patient cohorts, ARL6IP1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL6IP1-associated genes across cancer lineages are EGFR, FASN, and JNK_pT183_Y185. Each is linked with ARL6IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL6IP1-to-partner and partner-to-ARL6IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by ARL6IP1-low versus ARL6IP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL6IP1→partner) and Y-score (partner→ARL6IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.161	-2.584	.030	.011	3	1
UCEC	FASN →	+0.406	+3.169	.027	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.571	.016	.011	3	1
UCEC	Ku80 →	+0.238	+1.887	.030	.031	3	1
UCEC	MEK1 →	+0.415	+3.169	.014	.018	3	1
UCEC	Notch1 →	+0.159	+2.179	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR by ARL6IP1 expression — UCEC

Explore this box plot interactively →