ARL6

Across TCGA patient cohorts, ARL6 mutation is significantly associated with the RNA expression of many other genes, with 888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL6-associated genes across cancer lineages are LINC02317, FBXO7, and POLDIP3. Each is linked with ARL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL6-to-partner and partner-to-ARL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02317 grouped by ARL6-low versus ARL6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL6→partner) and Y-score (partner→ARL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02317 →	+0.209	+6.122	<.001	.002	3	2
UCEC	FBXO7 →	+0.446	+3.721	.006	<.001	3	1
UCEC	POLDIP3 →	+0.565	+3.625	.003	.001	3	1
UCEC	SBF1 →	+0.640	+2.606	.002	.006	3	1
UCEC	AP1B1 →	+0.648	+2.606	<.001	.006	3	1
UCEC	MIEF1 →	+0.602	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 888 associations by consensus.

LINC02317 by ARL6 expression — COAD

Explore this box plot interactively →